I have mild joint hypermobility. It's made me double jointed and puts me at extra risk of pelvic floor damage if I become pregnant.
My partner has Marfan syndrome, which is more debilitating. A martial arts injury to his back, plus pectus excavatum, has made the cartilage at the back of the ribs extra weak, and the ribs keep slipping out of alignment near the shoulder blades. Super painful. :((