I believe that the fundamental question in spirituality is: "what is the nature of reality?"

Its permutations include "what is the nature of consciousness?" (my true question and ultimate quest) and "what caused existence", "why does life exist", "how did reality come to be" etc.

But these are also the fundamental questions which drive science. All the greatest scientific discoveries came about because someone asked the fundamental spiritual question "what is the nature of reality?" and decided to try and find out.

The problem is that because organised religion opposed the freethinking spiritual scientists such as Galileo, Newton and Darwin, because it challenged their dualistic dogma and claim to ownership of spirituality (ironically an approach that is opposed to the very nature of true spirituality), "spirituality" gradually became seen as something that was opposed to science. And the fact that science was able to debunk many of the claims of organised religion meant that many people thought they thereby debunked spirituality. Because religion claimed to have a monopoly on spirituality.

It's sad. Cause the quest for science IS a profoundly spiritual quest. By its very nature. The scientific method is a "dharma" essentially, a particular "method" to find truths about the nature of reality. It's not the ONLY method.